COMPREHENSIVE REVIEW ON NANOCRYSTAL TECHNOLOGY IN PHARMACEUTICAL FORMULATIONS

Many techniques have been developed to overcome the bioavailability problem of poorly soluble drugs. The nanonization is one in that micronized particle converted nanoparticle. Several processes are applied for nanocrystal production, including precipitation, milling, high pressure homogenization and combination method. formulation administered via various routes like oral, intravenous, intramuscular, pulmonary, ocular dermal but due safety, patient compliance ease administration, oral drug delivery preferred. There two basic ways prepare nanocrystals “bottom-up” “top-down” technologies. present literature provides an overview achievement improving by using different methods.